Sequence Selective Recognition of Biologically Relevant RNA Duplexes
نویسندگان
چکیده
منابع مشابه
Biologically Relevant Multiple Sequence
BIOLOGICALLY RELEVANT MULTIPLE SEQUENCE ALIGNMENT Hyrum D. Carroll Department of Computer Science Doctor of Philosophy Researchers use multiple sequence alignment algorithms to detect conserved regions in genetic sequences and to identify drug docking sites for drug development. In this dissertation, a novel algorithm is presented for using physicochemical properties to increase the accuracy of...
متن کاملBiologically Relevant Multiple Sequence Alignment
BIOLOGICALLY RELEVANT MULTIPLE SEQUENCE ALIGNMENT Hyrum D. Carroll Department of Computer Science Doctor of Philosophy Researchers use multiple sequence alignment algorithms to detect conserved regions in genetic sequences and to identify drug docking sites for drug development. In this dissertation, a novel algorithm is presented for using physicochemical properties to increase the accuracy of...
متن کاملSequence-Selective Formation of Synthetic H-Bonded Duplexes
Oligomers equipped with a sequence of phenol and pyridine N-oxide groups form duplexes via H-bonding interactions between these recognition units. Reductive amination chemistry was used to synthesize all possible 3-mer sequences: AAA, AAD, ADA, DAA, ADD, DAD, DDA, and DDD. Pairwise interactions between the oligomers were investigated using NMR titration and dilution experiments in toluene. The ...
متن کاملRecognition of RNA duplexes by chemically modified triplex-forming oligonucleotides
Triplex is emerging as an important RNA tertiary structure motif, in which consecutive non-canonical base pairs form between a duplex and a third strand. RNA duplex region is also often functionally important site for protein binding. Thus, triplex-forming oligonucleotides (TFOs) may be developed to regulate various biological functions involving RNA, such as viral ribosomal frameshifting and r...
متن کاملSequence recognition in the pairing of DNA duplexes.
Pairing of DNA fragments with homologous sequences occurs in gene shuffling, DNA repair, and other vital processes. While chemical individuality of base pairs is hidden inside the double helix, x ray and NMR revealed sequence-dependent modulation of the structure of DNA backbone. Here we show that the resulting modulation of the DNA surface charge pattern enables duplexes longer than approximat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biomolecular Research & Therapeutics
سال: 2012
ISSN: 2167-7956
DOI: 10.4172/2167-7956.1000e102